Rakesh C Kukreja Selected Research

Dimethyl Sulfoxide (DMSO)

1/2017	Reperfusion Therapy with Rapamycin Attenuates Myocardial Infarction through Activation of AKT and ERK.
5/2015	Inhibition of mammalian target of rapamycin protects against reperfusion injury in diabetic heart through STAT3 signaling.
12/2014	Tadalafil prevents acute heart failure with reduced ejection fraction in mice.
1/2012	Anti-inflammatory and cardioprotective effects of tadalafil in diabetic mice.
8/2006	Rapamycin confers preconditioning-like protection against ischemia-reperfusion injury in isolated mouse heart and cardiomyocytes.
11/2004	Opening of Ca2+-activated K+ channels triggers early and delayed preconditioning against I/R injury independent of NOS in mice.
4/2004	Protein kinase C plays an essential role in sildenafil-induced cardioprotection in rabbits.

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Rakesh C Kukreja Research Topics

Disease

42	Ischemia 12/2020 - 02/2002
37	Reperfusion Injury 01/2021 - 03/2002
37	Infarction (Infarctions) 11/2020 - 02/2002
30	Myocardial Infarction 12/2020 - 01/2006
17	Neoplasms (Cancer) 12/2020 - 05/2008
17	Necrosis 09/2015 - 03/2002
15	Cardiotoxicity 01/2020 - 04/2005
14	Heart Failure 01/2018 - 06/2007
12	Myocardial Ischemia (Ischemic Heart Diseases) 01/2021 - 01/2005
11	Erectile Dysfunction 03/2015 - 09/2002
10	Cardiomyopathies (Cardiomyopathy) 12/2014 - 04/2005
8	Inflammation (Inflammations) 01/2021 - 09/2007
7	Hypoxia (Hypoxemia) 04/2015 - 12/2004
7	Cardiomegaly (Heart Hypertrophy) 03/2015 - 03/2008
6	Cardiovascular Diseases (Cardiovascular Disease) 01/2018 - 02/2008
5	Body Weight (Weight, Body) 08/2020 - 01/2006
4	Prostatic Neoplasms (Prostate Cancer) 11/2020 - 10/2010
4	Insulin Resistance 12/2017 - 02/2008
4	Left Ventricular Dysfunction 05/2012 - 04/2005
3	Hypertrophy 01/2018 - 10/2010
3	Fibrosis (Cirrhosis) 01/2018 - 06/2011
3	Type 2 Diabetes Mellitus (MODY) 01/2017 - 07/2013
3	Heart Diseases (Heart Disease) 03/2015 - 09/2009
3	Pulmonary Arterial Hypertension 03/2015 - 04/2005
3	Pulmonary Hypertension 01/2011 - 02/2004
2	Pancreatic Neoplasms (Pancreatic Cancer) 01/2020 - 09/2015
2	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 03/2015 - 01/2013
2	Ataxia Telangiectasia (Louis Bar Syndrome) 12/2014 - 03/2014
2	Pulmonary Edema 12/2014 - 03/2008
2	Coronary Restenosis 12/2012 - 08/2006
2	Obesity 04/2012 - 01/2012
2	Ventricular Dysfunction 05/2011 - 01/2006
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2021
1	Dyslipidemias (Dyslipidemia) 05/2020
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 05/2020

Drug/Important Bio-Agent (IBA)

28	Sildenafil Citrate (Viagra)FDA Link 11/2020 - 09/2002
26	Type 5 Cyclic Nucleotide PhosphodiesterasesIBA 11/2020 - 01/2005
18	Doxorubicin (Adriamycin)FDA LinkGeneric 12/2020 - 04/2005
15	Phosphodiesterase 5 InhibitorsIBA 11/2020 - 04/2005
15	Tadalafil (Cialis)FDA Link 05/2020 - 02/2004
10	Sirolimus (Rapamycin)FDA Link 01/2021 - 08/2006
10	Adenosine Triphosphate (ATP)IBA 01/2017 - 09/2002
8	Pharmaceutical PreparationsIBA 01/2017 - 04/2003
7	Dimethyl Sulfoxide (DMSO)FDA LinkGeneric 01/2017 - 04/2004
6	Vardenafil Dihydrochloride (Levitra)FDA Link 03/2015 - 02/2004
5	TOR Serine-Threonine KinasesIBA 12/2020 - 05/2015
5	NitratesIBA 05/2020 - 05/2011
5	Nitric Oxide (Nitrogen Monoxide)FDA Link 05/2020 - 04/2004
5	Proteins (Proteins, Gene)FDA Link 04/2018 - 05/2008
5	MicroRNAs (MicroRNA)IBA 01/2018 - 12/2008
5	Hydrogen Sulfide (Sulfide, Hydrogen)IBA 05/2015 - 09/2009
5	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 05/2012 - 02/2004
5	Small Interfering RNA (siRNA)IBA 02/2012 - 10/2005
5	5-hydroxydecanoic acidIBA 01/2008 - 09/2002
4	Glucose (Dextrose)FDA LinkGeneric 05/2020 - 01/2012
4	AnthracyclinesIBA 01/2018 - 05/2011
4	Reactive Oxygen Species (Oxygen Radicals)IBA 09/2015 - 12/2006
4	Trypan Blue FDA Link 05/2015 - 04/2005
4	Cyclic GMP-Dependent Protein Kinases (Protein Kinase G)IBA 03/2012 - 12/2006
4	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 12/2010 - 02/2002
4	mitochondrial K(ATP) channelIBA 01/2008 - 09/2002
3	EnzymesIBA 01/2021 - 01/2011
3	NitritesIBA 05/2020 - 05/2011
3	Triglycerides (Triacylglycerol)IBA 12/2017 - 01/2012
3	Sirtuin 1IBA 06/2014 - 12/2010
3	salicylhydroxamic acid (SHAM)IBA 05/2008 - 04/2004
2	dactolisibIBA 01/2020 - 09/2015
2	Connexin 43 (Connexin43)IBA 04/2018 - 04/2015
2	Insulin (Novolin)FDA Link 01/2017 - 02/2014
2	Death Domain ReceptorsIBA 01/2016 - 01/2006
2	Gemcitabine FDA Link 09/2015 - 03/2014
2	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 09/2015 - 12/2006
2	Biomarkers (Surrogate Marker)IBA 02/2015 - 10/2011
2	BAY 58-2667IBA 01/2015 - 03/2012
2	Cisplatin (Platino)FDA LinkGeneric 06/2014 - 03/2014
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 02/2012 - 10/2006
2	CytokinesIBA 01/2012 - 09/2007
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2012 - 11/2007
2	ChemokinesIBA 01/2012 - 09/2007
2	Transcription Factors (Transcription Factor)IBA 08/2011 - 02/2008
2	DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA 06/2011 - 03/2008
2	Cyclic NucleotidesIBA 01/2011 - 09/2009
2	Adenosine (Adenocard)FDA LinkGeneric 09/2008 - 03/2002
2	Saline SolutionIBA 05/2008 - 01/2005
2	parecoxibIBA 11/2007 - 06/2007
2	Interleukin-8 (Interleukin 8)IBA 09/2007 - 08/2005
2	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 12/2006 - 04/2005
2	triphenyltetrazoliumIBA 01/2006 - 01/2005
2	N(6)- (3- iodobenzyl)- 5'- N- methylcarboxamidoadenosineIBA 07/2003 - 03/2002
2	S-methylisothiopseudouroniumIBA 07/2002 - 02/2002
1	SphingosineIBA 01/2021
1	Nonesterified Fatty Acids (NEFA)IBA 01/2021
1	SphingolipidsIBA 01/2021
1	CeramidesIBA 01/2021
1	Mechanistic Target of Rapamycin Complex 1IBA 12/2020
1	Docetaxel (Taxotere)FDA Link 11/2020
1	LipidsIBA 05/2020

Therapy/Procedure

12	Therapeutics 01/2020 - 01/2009
7	Drug Therapy (Chemotherapy) 11/2020 - 05/2012
5	Ligation 12/2014 - 03/2008